Technical Status and Development Trend of Medical Dynamic Multi-leaf Collimator

Ran Zheng; Liqiang Wang

doi:10.6911/WSRJ.202508_11(8).0005

Authors

Ran Zheng
Liqiang Wang

DOI:

https://doi.org/10.6911/WSRJ.202508_11(8).0005

Keywords:

Multi-leaf collimator, Radiotherapy, Leakage rate, Conformality.

Abstract

Medical multi-leaf collimator technology, as one of the core technologies in radiotherapy, effectively enhances the accuracy and safety of treatment by precisely controlling the shape of the radiation beam. This article first reviews the overall situation of cancer treatment and the important position of radiotherapy. Then, it deeply analyzes the basic principles, structural composition, working mechanism of DMLC (Dynamic Multi-Leaf Collimator) technology and its specific applications in clinical radiotherapy. On this basis, it further analyzes the development overview of DMLC technology at home and abroad, covering major manufacturers, technical parameters, market changes and the progress of localization. Finally, the article discusses the current challenges faced by DMLC technology and looks forward to its future development trends and research directions.

Downloads

Download data is not yet available.

References

[1] ZHOU Jingrun, ZHU Shaolin, ZHU Lei, ZHANG Han, and HE Lemin, “Design and clinical application evaluation of multi-leaf collimators”, Chinese Journal of Medical Instrumentation, 2023, Vol. 32 (2), p202-208

[2] LIU Fubo, LI Guangjun1, SHEN Jiuling, LI Liqin, and BAI Sen, “A review of progress of real-time tumor tracking radiotherapy technology based on dynamic multi-leaf collimator”, Biomedical Engineering, 2017, Vol. 34 (1), p145-149

[3] Zhang Mengmeng, “Research of multi - leaf collimator”, Modern Instruments & Medical Treatment, 2023, Vol. 29 (3), p66-72

[4] Ravindra Shende, and Ganesh Patel, “Validation of Dosimetric Leaf Gap (DLG) prior to its implementation in Treatment Planning System(TPS): TrueBeamTM millennium 120 leaf MLC”, Practical Oncology And Radiotherapy, 2017, Vol. 22, p485-494

[5] LYU Jun, CHEN Liuli, WEN Ruijun, LONG Pengcheng, SHANG Leiming, and HU Liqin, “Structural Design and Penumbra Analysis of Dynamic Multi-leaf Collimator Leaf End”, Chinese Medical Instrumentation, 2023, Vol. 47 (4), p377-382

[6] YU Quan-da, and ZHENG Xue, “Failure analysis and maintenance of medical linear accelerator MLC”, China Medical Equipment, 2021, Vol. 18 (7), p186-188

[7] LUO Yu, “Elekta Synergy Medical Linear Accelerator Multi-Leaf Grating Troubleshooting and Repair”, Medical Equipment, 2019, Vol. 32 (13), p127-128

[8] GUO Zhao, “Technical Status and Development Trend of Dynamic Multileaf Grating Collimator”, China Medical Devices, 2021, Vol. 36 (1), p154-158

[9] CHEN Chaomin, “Research on Three-Dimensional Static Intensity-Modulated Radiation Therapy Technology”, Southern Medical University, 2007

[10] TAN Jian-feng, and LU Xu-we, “Dosimetric difference comparison between dynamic multi -leave collimators intensity -modulated radiotherapy and step shoot intensity-modulated radiotherapy in cervical cancer treatment”, BME ＆ Clin Med, 2019, Vol. 23 (6), p 661-665

[11] Qihui Lyu, Ryan Neph, Victoria Y Yu, Dan Ruan, and Ke Sheng, “Single-Arc VMAT optimization for Dual-Layer MLC”, Phy Med Biol, 2019, Vol. 64 (9), 095028

[12] Tze Yee Lim, Irena Dragojević, David Hoffman, Everardo Flores-Martinez, and Gwe-Ya Kim, “Characterization of the Halcyon multileaf collimator system”, Radiation Oncology Physics, 2019, Vol. 20 (7), p202-203

[13] Ryohei Miyasaka, SangYong Cho, Takuya Hiraoka, Kohei Chiba, Toru Kawachi, Tetsurou Katayose, Yuhi Suda, and Ryusuke Hara, “Investigation of Halcyon multi-leaf collimator model in Eclipse treatment planning system: A focus on the VMAT dose calculation with the Acuros XB algorithm”, Applied Clinical Medical Physics, 2022, Vol. 23 (3), e13519

[14] Rohani S. A., Mahdavi S. R., Mostaar A., Ueltzhöffer S., Mohammadi R., and Geraily Gh., “Physical and Dosimetric Aspect of Euromechanics Add-on Multileaf Collimator on Varian Clinac 2100 C/D”, J Biomed Phys Eng, 2019, Vol. 9 (1), p29-36

[15] XIE Chuanbina, SHEN Hongfenga, DAI Xiangkuna, GAO Wenchaob, WANG Junliangb, LIU Yanlia, YU weia, and QU Baolin, “Stability Analysis for Domestic Medical Linear Accelerator VenusX”, China Medical Devices, 2021, Vol. 36 (4), p61-64,75

[16] Cao Maomao, and Chen Wanqing, “Interpretation on the global cancer statistics of GLOBOCAN 2020”, Chinese Journal of the Frontiers of Medical Science (Electronic Version), 2021, Vol. 13 (3), p63-69

[17] MA Tianbin, JIANG Zhendong, YU Haidong, ZHANG Hanxiong, HU Dan, and CHEN Yibiao, “Multileaf collimators of two different leaf widths in radiotherapy of nasopharyngeal carcinoma: a dosimetric comparison”, Chinese Journal of Medical Physics, 2021, Vol. 38 (3), p302-307

[18] Zhang Chunlei, Zhang Hui, Ye Peiqing, and Zhang Luhong, “Inductance Analysis of Two-Phase Slotless Tubular Permanent Magnet Synchronous Linear Motor”, Transactions of China Electrotechnical Society, 2021, Vol. 38 (3), p1159-1168

[19] Peiris GS, Whelan B, Hardcastle N, and Sheehy SL, “The effect of multi-leaf collimator leaf width on VMAT treatment plan quality”, Journal of Applied Clinical Medical Physics, 2025, Vol. 26, e70018

[20] Yang Jiming, Ma Min, Wu Yong, and Ren Jiangping, “Tolerance and dosimetric study of multi-leaf collimator leaf position accuracy for dynamic intensity-modulated radiotherapy”, Chinese Journal of Radiation Oncology, 2021, Vol. 30 (11), p1167-1172

[21] Qiu M, Zhong J, Xiao Z, and Deng Y, “From plan to delivery: Machine learning based positional accuracy prediction of multi-leaf collimator and estimation of delivery effect in volumetric modulated arc therapy”, Journal of applied clinical medical physics, 2024, Vol. 25 (9), e14437

[22] Raj A, Khanna D, Vt H, Padmanabhan S, Mohandass P, “Evaluation of dosimetric effect of millennium and high definition multi leaf collimator using 6 MV photon beams”, Asian Pacific Journal of Cancer Prevention, 2021, Vol. 22 (12), p3883-3888

[23] Andrew Morrow, Nickolas Trisnadi, Heeteak Chung, “Multi-level multi-leaf collimators: Optimization of layer thicknesses and a feasibility study”, Medical Physics, 2022, Vol. 49 (2), p792-800

[24] Nels C. Knutson, PhD, William R. Kennedy, MD, Francisco J. Reynoso, PhD, Jiayuan Peng, MS, Lauren E. Henke, MD, Eric Laugeman, MS, Michael Watts, MS, Jessica Hillard, MS, Ana Heermann, AS, Geoffrey D. Hugo, PhD, Sasa Mutic, PhD and Bin Cai, and PhD, “Intracranial Stereotactic Radiation Therapy With a Jawless Ring Gantry Linear Accelerator Equipped With New Dual Layer Multileaf Collimator”, Advances in Radiation Oncology, 2020, Vol. 5 (3), p482-489

[25] LI Xiaohong1, MEI Jie2, LONG Hao3, and YANG Jing, “Study on the Performance of Two-Dimensional Semiconductor Matrix and Its Application in Dose Verification of Multi-Target Radiotherapy Plan”, China Medical Devices, 2022, Vol. 37 (4), p23-26,34

[26] SM Chae, GW Lee, and SH Son, “The effect of multileaf collimator leaf width on the radiosurgery planning for spine lesion treatment in terms of the modulated techniques and target complexity”, Radiation Oncology, 2014, Vol. 9 (1), p72

[27] YAO Jonathan Yi, “A Multiple layer multileaf collimator”, US, EP0751532B1[P], 1999

[28] MOSHE Ein-Gal, “Multiple layer multileaf collimator”, EP, US6266393B1[P], 2001

[29] ZHU Zhiqiang, CHENG Peng, CHEN Liuli, et al, “Technical Status and Development Trend of Medical Electron Linear Accelerators[J]”, Chinese Journal of Medical Instrumentation, 2024, Vol. 48 (2), p184-191

[30] Topolnjak R, Van der Heide UA, Raaymakers BW, et al, “A six-bank multi-leaf system for high precision shaping of large fields[J]”, Phys Med Biol, 2004, Vol. 49 (12), p2645-2656

[31] Chen Liuli, Lv Jun, Zhu Zhiqiang, Shang Leiming, Long Pengcheng, and Hu Liqin, “A Summary of Technical Development of Medical Dynamic Multi-leaf Collimator”, Medical Equipment, 2023 ,Vol. 36, (1), p156-160

[32] Zadnorouzi M, Abtahi SMM, “Artificial intelligence (AI) applications in improvement of IMRT and VMAT radiotherapy treatment planning processes: A systematic review”, Radiography, 2024 ,Vol. 9, (49), p1530-1535

[33] Fodil NE, Abdelhakem MM, Yahia GA, and Ammar H, “Evaluation of Dynamic Multi-Leaf Collimator (MLC) versus Fixed MLC for Intensity Modulated Radiotherapy (IMRT) Using the Agility 160-Leaf Collimator” 2024, Vol. 25, (7), p2467-2474